Dual receptor recognizing liposomes containing paclitaxel and hydroxychloroquine for primary and metastatic melanoma treatment via autophagy-dependent and independent pathways.
Identifieur interne : 000C39 ( Main/Exploration ); précédent : 000C38; suivant : 000C40Dual receptor recognizing liposomes containing paclitaxel and hydroxychloroquine for primary and metastatic melanoma treatment via autophagy-dependent and independent pathways.
Auteurs : Sheng Yin [République populaire de Chine] ; Chunyu Xia [République populaire de Chine] ; Yashi Wang [République populaire de Chine] ; Dandan Wan [République populaire de Chine] ; Jingdong Rao [République populaire de Chine] ; Xian Tang [République populaire de Chine] ; Jiaojie Wei [République populaire de Chine] ; Xuhui Wang [République populaire de Chine] ; Man Li [République populaire de Chine] ; Zhirong Zhang [République populaire de Chine] ; Ji Liu [République populaire de Chine] ; Qin He [République populaire de Chine]Source :
- Journal of controlled release : official journal of the Controlled Release Society [ 1873-4995 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Antinéoplasiques (administration et posologie), Autophagie (), Humains, Hydroxychloroquine (administration et posologie), Intégrine alphaVbêta3 (métabolisme), Lignée cellulaire, Liposomes, Mélanome (anatomopathologie), Mélanome (métabolisme), Mélanome (traitement médicamenteux), Neuropiline 1 (métabolisme), Oligopeptides (administration et posologie), Paclitaxel (administration et posologie), Paxilline (métabolisme), Phosphatidyléthanolamine (administration et posologie), Polyéthylène glycols (administration et posologie), Protocoles de polychimiothérapie antinéoplasique (administration et posologie), Récepteurs CXCR4 (métabolisme), Souris de lignée C57BL, Tumeurs du poumon (secondaire), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- administration et posologie : Antinéoplasiques, Hydroxychloroquine, Oligopeptides, Paclitaxel, Phosphatidyléthanolamine, Polyéthylène glycols, Protocoles de polychimiothérapie antinéoplasique.
- anatomopathologie : Mélanome.
- métabolisme : Intégrine alphaVbêta3, Mélanome, Neuropiline 1, Paxilline, Récepteurs CXCR4.
- secondaire : Tumeurs du poumon.
- traitement médicamenteux : Mélanome, Tumeurs du poumon.
- Animaux, Autophagie, Humains, Lignée cellulaire, Liposomes, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Antineoplastic Agents (administration & dosage), Antineoplastic Combined Chemotherapy Protocols (administration & dosage), Autophagy (drug effects), Cell Line, Humans, Hydroxychloroquine (administration & dosage), Integrin alphaVbeta3 (metabolism), Liposomes, Lung Neoplasms (drug therapy), Lung Neoplasms (secondary), Melanoma (drug therapy), Melanoma (metabolism), Melanoma (pathology), Mice, Inbred C57BL, Neuropilin-1 (metabolism), Oligopeptides (administration & dosage), Paclitaxel (administration & dosage), Paxillin (metabolism), Phosphatidylethanolamines (administration & dosage), Polyethylene Glycols (administration & dosage), Receptors, CXCR4 (metabolism).
- MESH :
- chemical , administration & dosage : Antineoplastic Agents, Hydroxychloroquine, Oligopeptides, Paclitaxel, Phosphatidylethanolamines, Polyethylene Glycols.
- administration & dosage : Antineoplastic Combined Chemotherapy Protocols.
- drug effects : Autophagy.
- drug therapy : Lung Neoplasms, Melanoma.
- chemical , metabolism : Integrin alphaVbeta3, Melanoma, Neuropilin-1, Paxillin, Receptors, CXCR4.
- pathology : Melanoma.
- secondary : Lung Neoplasms.
- Animals, Cell Line, Humans, Liposomes, Mice, Inbred C57BL.
Abstract
Autophagy acts as a cytoprotective mechanism for malignant tumors, thus maintaining the survival and promoting proliferation and metastasis of malignant tumors. Recent studies have showed that autophagy inhibitors can enhance the chemotherapeutic efficacy of anti-tumor growth. However, the antimetastasis effects and the possible mechanisms of chemotherapeutics combined with autophagy inhibitors have not been thoroughly explored. Here, we prepared R8-dGR peptide modified paclitaxel (PTX) and hydroxychloroquine (HCQ) co-loaded liposomes (PTX/HCQ-R8-dGR-Lip) for enhanced delivery by recognizing integrin αvβ3 receptors and neuropilin-1 receptors on B16F10 melanoma cells. Our results showed that R8-dGR modified liposomes (R8-dGR-Lip) enhanced tumor-targeting delivery in vitro and in vivo. Besides, PTX/HCQ-R8-dGR-Lip exhibited the optimum inhibitory effects on migration, invasion and anoikis resistance of B16F10 cells in vitro, and showed enhanced efficiency on inhibiting primary tumor growth and reducing lung metastasis in vivo. Meanwhile, the antimetastasis mechanism studies confirmed that the combination of the chemotherapeutic PTX and the autophagy inhibitor HCQ further suppressed the degradation of paxillin, the expression of MMP9 and MMP2. Moreover, HCQ disturbed the CXCR4/CXCL12 axis which could induce invasion and metastasis of malignant melanoma in an autophagy-independent way.
DOI: 10.1016/j.jconrel.2018.08.015
PubMed: 30099017
Affiliations:
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Le document en format XML
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populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Chunyu" sort="Xia, Chunyu" uniqKey="Xia C" first="Chunyu" last="Xia">Chunyu Xia</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yashi" sort="Wang, Yashi" uniqKey="Wang Y" first="Yashi" last="Wang">Yashi Wang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Wan, Dandan" sort="Wan, Dandan" uniqKey="Wan D" first="Dandan" last="Wan">Dandan Wan</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Jingdong" sort="Rao, Jingdong" uniqKey="Rao J" first="Jingdong" last="Rao">Jingdong Rao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Xian" sort="Tang, Xian" uniqKey="Tang X" first="Xian" last="Tang">Xian Tang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Jiaojie" sort="Wei, Jiaojie" uniqKey="Wei J" first="Jiaojie" last="Wei">Jiaojie Wei</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Xuhui" sort="Wang, Xuhui" uniqKey="Wang X" first="Xuhui" last="Wang">Xuhui Wang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Zhirong" sort="Zhang, Zhirong" uniqKey="Zhang Z" first="Zhirong" last="Zhang">Zhirong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Ji" sort="Liu, Ji" uniqKey="Liu J" first="Ji" last="Liu">Ji Liu</name><affiliation wicri:level="1"><nlm:affiliation>West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China. Electronic address: liuji6103@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author><author><name sortKey="He, Qin" sort="He, Qin" uniqKey="He Q" first="Qin" last="He">Qin He</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China. Electronic address: qinhe317@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041</wicri:regionArea><wicri:noRegion>Chengdu 610041</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of controlled release : official journal of the Controlled Release Society</title><idno type="eISSN">1873-4995</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antineoplastic Agents (administration & dosage)</term><term>Antineoplastic Combined Chemotherapy Protocols (administration & dosage)</term><term>Autophagy (drug effects)</term><term>Cell Line</term><term>Humans</term><term>Hydroxychloroquine (administration & dosage)</term><term>Integrin alphaVbeta3 (metabolism)</term><term>Liposomes</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (secondary)</term><term>Melanoma (drug therapy)</term><term>Melanoma (metabolism)</term><term>Melanoma (pathology)</term><term>Mice, Inbred C57BL</term><term>Neuropilin-1 (metabolism)</term><term>Oligopeptides (administration & dosage)</term><term>Paclitaxel (administration & dosage)</term><term>Paxillin (metabolism)</term><term>Phosphatidylethanolamines (administration & dosage)</term><term>Polyethylene Glycols (administration & dosage)</term><term>Receptors, CXCR4 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antinéoplasiques (administration et posologie)</term><term>Autophagie ()</term><term>Humains</term><term>Hydroxychloroquine (administration et posologie)</term><term>Intégrine alphaVbêta3 (métabolisme)</term><term>Lignée cellulaire</term><term>Liposomes</term><term>Mélanome (anatomopathologie)</term><term>Mélanome (métabolisme)</term><term>Mélanome (traitement médicamenteux)</term><term>Neuropiline 1 (métabolisme)</term><term>Oligopeptides (administration et posologie)</term><term>Paclitaxel (administration et posologie)</term><term>Paxilline (métabolisme)</term><term>Phosphatidyléthanolamine (administration et posologie)</term><term>Polyéthylène glycols (administration et posologie)</term><term>Protocoles de polychimiothérapie antinéoplasique (administration et posologie)</term><term>Récepteurs CXCR4 (métabolisme)</term><term>Souris de lignée C57BL</term><term>Tumeurs du poumon (secondaire)</term><term>Tumeurs du poumon (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Agents</term><term>Hydroxychloroquine</term><term>Oligopeptides</term><term>Paclitaxel</term><term>Phosphatidylethanolamines</term><term>Polyethylene Glycols</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Hydroxychloroquine</term><term>Oligopeptides</term><term>Paclitaxel</term><term>Phosphatidyléthanolamine</term><term>Polyéthylène glycols</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mélanome</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Neoplasms</term><term>Melanoma</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Integrin alphaVbeta3</term><term>Melanoma</term><term>Neuropilin-1</term><term>Paxillin</term><term>Receptors, CXCR4</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Intégrine alphaVbêta3</term><term>Mélanome</term><term>Neuropiline 1</term><term>Paxilline</term><term>Récepteurs CXCR4</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Melanoma</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Mélanome</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Liposomes</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autophagie</term><term>Humains</term><term>Lignée cellulaire</term><term>Liposomes</term><term>Souris de lignée C57BL</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Autophagy acts as a cytoprotective mechanism for malignant tumors, thus maintaining the survival and promoting proliferation and metastasis of malignant tumors. Recent studies have showed that autophagy inhibitors can enhance the chemotherapeutic efficacy of anti-tumor growth. However, the antimetastasis effects and the possible mechanisms of chemotherapeutics combined with autophagy inhibitors have not been thoroughly explored. Here, we prepared R8-dGR peptide modified paclitaxel (PTX) and hydroxychloroquine (HCQ) co-loaded liposomes (PTX/HCQ-R8-dGR-Lip) for enhanced delivery by recognizing integrin αvβ3 receptors and neuropilin-1 receptors on B16F10 melanoma cells. Our results showed that R8-dGR modified liposomes (R8-dGR-Lip) enhanced tumor-targeting delivery in vitro and in vivo. Besides, PTX/HCQ-R8-dGR-Lip exhibited the optimum inhibitory effects on migration, invasion and anoikis resistance of B16F10 cells in vitro, and showed enhanced efficiency on inhibiting primary tumor growth and reducing lung metastasis in vivo. Meanwhile, the antimetastasis mechanism studies confirmed that the combination of the chemotherapeutic PTX and the autophagy inhibitor HCQ further suppressed the degradation of paxillin, the expression of MMP9 and MMP2. Moreover, HCQ disturbed the CXCR4/CXCL12 axis which could induce invasion and metastasis of malignant melanoma in an autophagy-independent way.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yin, Sheng" sort="Yin, Sheng" uniqKey="Yin S" first="Sheng" last="Yin">Sheng Yin</name></noRegion><name sortKey="He, Qin" sort="He, Qin" uniqKey="He Q" first="Qin" last="He">Qin He</name><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><name sortKey="Liu, Ji" sort="Liu, Ji" uniqKey="Liu J" first="Ji" last="Liu">Ji Liu</name><name sortKey="Rao, Jingdong" sort="Rao, Jingdong" uniqKey="Rao J" first="Jingdong" last="Rao">Jingdong Rao</name><name sortKey="Tang, Xian" sort="Tang, Xian" uniqKey="Tang X" first="Xian" last="Tang">Xian Tang</name><name sortKey="Wan, Dandan" sort="Wan, Dandan" uniqKey="Wan D" first="Dandan" last="Wan">Dandan Wan</name><name sortKey="Wang, Xuhui" sort="Wang, Xuhui" uniqKey="Wang X" first="Xuhui" last="Wang">Xuhui Wang</name><name sortKey="Wang, Yashi" sort="Wang, Yashi" uniqKey="Wang Y" first="Yashi" last="Wang">Yashi Wang</name><name sortKey="Wei, Jiaojie" sort="Wei, Jiaojie" uniqKey="Wei J" first="Jiaojie" last="Wei">Jiaojie Wei</name><name sortKey="Xia, Chunyu" sort="Xia, Chunyu" uniqKey="Xia C" first="Chunyu" last="Xia">Chunyu Xia</name><name sortKey="Zhang, Zhirong" sort="Zhang, Zhirong" uniqKey="Zhang Z" first="Zhirong" last="Zhang">Zhirong Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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